Abstract:

Aim: was to study the diagnostic and prognostic importance of impedance indicators of a kidney parenchyma at acute (ARI) and chronic renal insufficiency (CRI).

Material and methods. Research was performed on the basis of a hemodialysis department. 51 patients were examined during the period from 2009 till 2010. They underewent a monopolar bioimpedance measurement of kidneys under ultrasound control.

Results. Changes of absolute and relative indicators of electric impedance of a kidney parenchyma show morphological violations in organ at acute and chronic renal insufficiency, characterize evidence of compensatory processes and give information on a tissue functional activity. These data are necessary for verification of the diagnosis, prescription of reasonable pharmacotherapy and definition of a pathological process forecast.

Abstract:

Aim: was to assess biophysical parameters of a renal parenchyma at experimental acute and chronic renal insufficiency at rats.

Material and methods. Experiment was carried out on 36 rats of both sexes in mass of 180-250 g. The bioimpedance analysis of a renal parenchyma was carried out in intraoperative way on the 7th day after modeling of acute renal insufficiency and 2 months later after modeling of acute renal insufficiency, using «G. Greven's method». Absolute and relative indicators of electric impedance were investigated.

Results. Chronic renal insufficiency in contrast to the acute renal insufficiency is characterized not only by reduction of absolute indicators of renal parenchyma electric impedance, but also by change of relative indicators. Apparently, relative indicators of the bioimpedance analysis reflect change of the renal parenchyma functional status and absolute peculiarities of its morphological structure.

Conclusion. The analysis of results of a bioimpedansometriya in separate zones of a kidney, showed that in a normal kidney the electric impedance in various parts of body is non-uniform, however at renal insufficiency indicators of an impedance are leveled. This phenomenon is necessary for checking in clinical researches and, in case of confirmation of experimental results, it can be used as diagnostic criterion at statement of the diagnosis of acute renal insufficiency.

References 

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Abstract:

Diffuse liver lesion is one of the leading positions in the structure of hepatobiliary pathology Dispite the large number of available diagnostic methods biopsy followed by histological examination is a «gold standart» untill now. Bioimpedancemetry is a potential method of evaluation of morpho-functional analysys of the organ.

Aim: was to clarify dependence of indices of an electrical impedance of liver tissue on its morfo-functional status and to define general valuation principles of absolute and relative measures of an electrical impedance of an organ in case of liver diffusion pathology in an experiment.

Metarials and methods: the experimental study was carried out on 66 Wistar rats 180-230 g. The diffuse liver failure was modeled by using 0,02% solution of N-nitrozodiethylamin with water that animals were drinking during all the period of experiment (120 days). Bioimpedancemetry and morphological investigation as a next step were performed on 14, 30, 60, 90, 120 days in parallel with biochemical blood analysis, sonography of the liver and morphological analysis.

Results: biophysical parameters of liver's parenchyma in cases of toxic hepatitis were characterized by increasing of absolute bioimpedance indices more than 50% and increasing of impedance dispersion coefficient of 16%. But in cases of drrhosis of the liver biophysical paremeters were characterized by decreasing of absolute indices of electrical impedance and increasing of heterogeneity coefficient of the liver of 50 to 100% at different measurement frequencies.

Conclusion: obtained data confirm the diagnostic value of bioimpedancemetry and give prerequisites for further studying of parameters of an electric impedance of liver parenchyma in clinical practice.  

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